Acute intermittent porphyria

Because I have a History of Hemochromatosis and high Cholesterol Levels and Low Sodium and low Platelets, and elevated Hemoglobin and Methemoglobinemia that causes Hypoglycemia and Metabolic Acidosis and Renal Tubular Acidosis and raises my AST and ALT and Antinuclear Antibody Levels, and causes Paralysis from the the waist down, and causes Vertigo and loss of Balance from Eustachian Tube Dysfunction, as it causes all the clinical manifestations of Acute Intermittent Porphyria, triggered by the same things that trigger Acute Intermittent Porphyria, I had a Doctor run these Tests.


They were negative for Porphyria, but were Positive for Heavy Metal Poisoning caused by Contaminated Water from a busted underground Water Pipe supplied by the VA, and most of the  Doctors actually believe that because it is negative for a Porphyria, it is ok to keep forcing upon me all the things that cause episodes that resemble  Acute Intermittent Porphyria, causing acute episodes of Hemochromatosis and high Cholesterol Levels and Low Sodium and low Platelets, and elevated Hemoglobin and Methemoglobinemia that causes Hypoglycemia and Metabolic Acidosis and Renal Tubular Acidosis and raises my AST and ALT and Antinuclear Antibody Levels, and causes Paralysis from the the waist down, and causes Vertigo and loss of Balance from Eustachian Tube Dysfunction.

 To:

Chinasa Paul Anugwom, MD, MD
From:

Joseph R Loegering
Sent:

3/3/2013  9:52 PM CST

"Patients with AIP are commonly misdiagnosed with psychiatric diseases. Subsequent treatment with anti-psychotics increases the accumulation of porphobilinogen, thus aggravating the disease enough that it may prove fatal."

Infections trigger acute episodes that last days to weeks, and takes much longer to recover from.

See

http://en.wikipedia.org/wiki/Acute_intermittent_porphyria

http://rarediseasesnetwork.epi.usf.edu/porphyrias/patients/AIP/

With AIP on top of a variant Lysozyme Polysaccharide Intolerance disorder that damages the Mucosa and causes Cirrhosis of the Liver, caused by the toxicity of High Iron Levels, they nearly killed me with a misdiagnosis and foods and drugs and inert Ingredients that elevated my ANA and or Iron, and Fe Saturation, and Ferritin Levels, every time I was Hospitalized, and by refusing to run the right Medical tests when needed, urinary, stool and/or plasma porphyrins and porphyrin precursors (ALA and PBG), during acute episodes, which is the only time that these things may be off, besides the Iron Levels, which is why the Medical Journals say that it is hard to diagnose.

I need Fairview or the VA to run those tests during the next acute episode.

And so that I can adjust my Diet for calcium and Vitamin D without causing an acute attack by elevating the Iron Levels, I need these Blood and Urine Tests run at the VA or Fairview at least once a Month so that I can adjust my Diet to correct the Problems, but the Doctors refuse to do it, and are causing me to have Gut Bleeding again by their Arrogance and Incompetence and Psychosis. Iron, Fe Saturation, Ferritin, and Blood Copper, with a Comprehensive Metabolic Panel, Vitamin D Test, and CBC and DIFFs, LIPID REFLEX TO DIRECT LDL PANEL, AMYLASE and LIPASE, Blood Ammonia and Lactic Acid, and UA MACRO REFLEX MICRO and Culture. And I need the Medications that I have repeatedly told the Doctors that I use when they cause those episodes.

Thanks

Lord Joseph

Notice here too, that this Doctor, like the other Doctors, will never run the same Tests that were thrown off during acute episodes before, like I told her about the Ferritin Levels too, and she ran a Ferritin Level separate, and would run no CBC and DIFFs, even though I told her my Platelet Levels drop during the different stages of the episodes. I did get her to run a Metabolic Panel and a Hepatitis  Viral Count, that shows that these Doctors are nuts about my Hepatitis and AST and ALT Levels. But along with the Hemoglobin Level that elevates first at the beginning of an episode, then the Serum Iron elevates, but the Ferritin Level is normally the first thing thrown off when an episode starts, and these episodes can be triggered by a Polysaccharide Encapsulated Bacteria, or some Fungi, or some Beta-glucan Foods or Inert Ingredients, that raise my ANA Level, but they always refuse to run those Tests when an episode starts, and often falsely call me delusional about the pain, because on the limited Tests that they did run, they could find nothing off.

 

Component	Your Value	Standard Range	Units
Iron	60	35 - 180	ug/dL
Iron Binding Cap	370	240 - 430	ug/dL
Iron Saturation Index	16	15 - 46	%

Ferritin 105 20 - 300 ng/mL

 General Information

Collected:

3/14/2013 2:38 PM

Resulted:

3/14/2013 3:32 PM

Ordered By:

Purvi D Gada, MD, MD

Result Status:

Final result

 

Here are two of my VA Iron Level Tests that show how fast my Iron Levels change in less than two weeks and cause the episodes.

Fe Serum range 65/175 ug/dl 10/18/2006-180 H 10/30/2006-324 H

Fe Saturation range 14/50 percent 10/18/2006-46.8 10/30/2006-85.9 H

Ferritin 22/322 ng/ml 10/18/2006-433.7 H 10/30/2006-713 H

Total Iron Binding Capacity 250/500 ug/dl 10/18/2006-385 10/30/2006-377

TRANSFE 200/360 ng/dl 10/18/2006-303 10/30/2006-297


On this Tests if Coproporphyrin I which is maxed here, becomes higher than Coproporphyrin III which is high here, that would be from extra Bilirubin caused by an acute episode of Methemoglobinemia  and or an acute episode of Hemochromatosis from where the extra Hemoglobin and Methemoglobin is being broken down by the Spleen to produce Bilirubin, which the Spleen where I have a small incidental Benign Calcification, also recycles the Iron from Hemoglobin and Methemoglobin and old red blood cells, but when Coproporphyrin III is higher than Coproporphyrin I like it is here, that is from Heavy Metal Poisoning, and since the Building next door tested positive for Lead in the Water, it is most likely elevated here from Lead Poisoning, and not so much Mercury, whic exposure to Mercury could be a part of it, from the increase of Tuna in my Diet over the Past Year, which is what I first suspected from the symptoms I was having, that were similar yo when a got Mercury Poisoning from a broken Thermometer as a Child, but it turned out to most likely be Lead this time, but with normal Red Blood Cell Level and elevated Hemoglobin and Hematocrit and low end CO2 and occasional Nitrite and or Bilirubin and or Urobilinogen  in the Urine with no apparent Bacteria, and this maxed Coproporphyrin I, that is typical of mild Methemoglobinemia with Heavy Metal Poisoning.

 

ARUP MISCELLANEOUS TEST

Result Notes

Notes Recorded by Gada, Purvi D, MD on 3/20/2013 at 1:37 PM
Please notify pt, that urine porphyrin studies are normal.

Thanks,
Purvi

Component Results

Component	Your Value	Standard Range	Units
Result	SEE NOTE (Note) Test name Result Units RefIntvl ------------------------------------------------------------ Uroporphyrin - ratio to CRT 2 umol/mol CRT 0-4 Heptacarboxylate - ratio to CRT 1 umol/mol CRT 0-2 Coproporphyrin I - ratio to CRT 6 umol/mol CRT 0-6 Coproporphyrin III - ratio to CRT 16 H umol/mol CRT 0-14 Porphobilinogen (PBG), Urine -per volume <  3 umol/L 0.0-8.8 Porphobilinogen (PBG), Urine -per 24h Not Applicable umol/d 0.0-11.0 Creatinine, Urine - per volume 34 mg/dL Creatinine, Urine - per 24h Not Applicable mg/d 800-2100 Porphyrin Urine Interpretation See Note Elevated coproporphyrin concentration is a relatively common finding and may be the result of diet, liver disease, disorders of bilirubin metabolism, or other diverse conditions. An isolated increase in urine coproporphyrin concentration is not diagnostic of a porphyrin disorder. INTERPRETIVE INFORMATION: Porphyrins, Fractionation and Quantitation, Urine Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine). Performed by ARUP Laboratories, 500 Chipeta Way, SLC,UT 84108 800-522-2787 www.aruplab.com, Sherrie L. Perkins, MD, Lab. Director
Test Name	PORPHYRINS AND PORPHOBILINOGEN
Send Outs Misc Test Code	2002181
Send Outs Misc Test Specimen